1 00:00:00,600 --> 00:00:01,501 [calm droning music] 2 00:00:01,601 --> 00:00:04,104 - So we define autism as a behavioral syndrome, 3 00:00:04,838 --> 00:00:06,606 which means it's a co-occurrence 4 00:00:06,706 --> 00:00:08,975 of certain behavioral phenomena. 5 00:00:09,075 --> 00:00:11,077 There are two key phenomenon. 6 00:00:11,177 --> 00:00:14,247 One are certain kinds of social deficits. 7 00:00:14,347 --> 00:00:18,151 Deficits in regards to social interaction. 8 00:00:18,251 --> 00:00:19,753 And the other domain is a little bit of 9 00:00:19,853 --> 00:00:22,689 a messier umbrella term. 10 00:00:22,789 --> 00:00:26,259 We use the term ritualistic repetitive behaviors. 11 00:00:26,359 --> 00:00:29,429 [calm droning music] 12 00:00:40,407 --> 00:00:43,309 Autism is defined by behaviors only. 13 00:00:43,410 --> 00:00:45,211 So it's very different from diabetes 14 00:00:45,311 --> 00:00:46,780 that we have a very specific 15 00:00:46,880 --> 00:00:49,816 biological test about insulin levels, 16 00:00:49,916 --> 00:00:53,787 or a sickle cell that we know is due to a single gene. 17 00:00:55,221 --> 00:00:59,192 And as a result, it's a bit of a hodgepodge, frankly. 18 00:00:59,292 --> 00:01:02,462 [calm droning music] 19 00:01:08,635 --> 00:01:12,372 It's defined clinically on the basis of these behaviors 20 00:01:12,472 --> 00:01:15,275 because currently that's what we treat. 21 00:01:15,375 --> 00:01:18,745 But what we've learned over the last 10 or 15 years 22 00:01:18,845 --> 00:01:20,880 particularly from genetics 23 00:01:20,980 --> 00:01:23,550 is that there are multiple autisms. 24 00:01:23,650 --> 00:01:24,951 We have some people with autism 25 00:01:25,051 --> 00:01:26,653 that have intellectual disability. 26 00:01:26,753 --> 00:01:29,255 What used to be termed mental retardation. 27 00:01:29,355 --> 00:01:31,958 We have some that have high IQ's. 28 00:01:32,058 --> 00:01:34,561 We have some that have more severe ritualistic 29 00:01:34,661 --> 00:01:36,429 and repetitive behaviors, and some 30 00:01:36,529 --> 00:01:39,165 that have milder ritualistic and repetitive behaviors. 31 00:01:39,265 --> 00:01:41,234 As we sort of look under the hood, 32 00:01:41,334 --> 00:01:43,903 when we look at the brain or we look at genetics, 33 00:01:45,004 --> 00:01:47,774 based on defining people as having autism, 34 00:01:47,874 --> 00:01:50,210 we find a bunch of different stuff, 35 00:01:50,310 --> 00:01:53,379 and that's essentially a problem in our field 36 00:01:53,480 --> 00:01:56,249 because we find too much.