WEBVTT 00:00.600 --> 00:01.501 align:left position:25% line:89% size:65% [calm droning music] 00:01.601 --> 00:04.104 align:left position:20% line:83% size:70% - So we define autism as a behavioral syndrome, 00:04.838 --> 00:06.606 align:left position:10% line:5% size:80% which means it's a co-occurrence 00:06.706 --> 00:08.975 align:left position:10% line:5% size:80% of certain behavioral phenomena. 00:09.075 --> 00:11.077 align:left position:15% line:5% size:75% There are two key phenomenon. 00:11.177 --> 00:14.247 align:left position:25% line:83% size:65% One are certain kinds of social deficits. 00:14.347 --> 00:18.151 align:left position:22.5% line:83% size:67.5% Deficits in regards to social interaction. 00:18.251 --> 00:19.753 align:left position:25% line:83% size:65% And the other domain is a little bit of 00:19.853 --> 00:22.689 align:left position:20% line:89% size:70% a messier umbrella term. 00:22.789 --> 00:26.259 align:left position:17.5% line:83% size:72.5% We use the term ritualistic repetitive behaviors. 00:26.359 --> 00:29.429 align:left position:25% line:89% size:65% [calm droning music] 00:40.407 --> 00:43.309 align:left position:27.5% line:83% size:62.5% Autism is defined by behaviors only. 00:43.410 --> 00:45.211 align:left position:22.5% line:83% size:67.5% So it's very different from diabetes 00:45.311 --> 00:46.780 align:left position:15% line:89% size:75% that we have a very specific 00:46.880 --> 00:49.816 align:left position:25% line:83% size:65% biological test about insulin levels, 00:49.916 --> 00:53.787 align:left position:15% line:83% size:75% or a sickle cell that we know is due to a single gene. 00:55.221 --> 00:59.192 align:left position:17.5% line:83% size:72.5% And as a result, it's a bit of a hodgepodge, frankly. 00:59.292 --> 01:02.462 align:left position:25% line:89% size:65% [calm droning music] 01:08.635 --> 01:12.372 align:left position:15% line:83% size:75% It's defined clinically on the basis of these behaviors 01:12.472 --> 01:15.275 align:left position:25% line:83% size:65% because currently that's what we treat. 01:15.375 --> 01:18.745 align:left position:17.5% line:83% size:72.5% But what we've learned over the last 10 or 15 years 01:18.845 --> 01:20.880 align:left position:17.5% line:89% size:72.5% particularly from genetics 01:20.980 --> 01:23.550 align:left position:30% line:83% size:60% is that there are multiple autisms. 01:23.650 --> 01:24.951 align:left position:10% line:89% size:80% We have some people with autism 01:25.051 --> 01:26.653 align:left position:22.5% line:83% size:67.5% that have intellectual disability. 01:26.753 --> 01:29.255 align:left position:22.5% line:83% size:67.5% What used to be termed mental retardation. 01:29.355 --> 01:31.958 align:left position:30% line:83% size:60% We have some that have high IQ's. 01:32.058 --> 01:34.561 align:left position:22.5% line:83% size:67.5% We have some that have more severe ritualistic 01:34.661 --> 01:36.429 align:left position:27.5% line:83% size:62.5% and repetitive behaviors, and some 01:36.529 --> 01:39.165 align:left position:15% line:83% size:75% that have milder ritualistic and repetitive behaviors. 01:39.265 --> 01:41.234 align:left position:27.5% line:83% size:62.5% As we sort of look under the hood, 01:41.334 --> 01:43.903 align:left position:20% line:83% size:70% when we look at the brain or we look at genetics, 01:45.004 --> 01:47.774 align:left position:20% line:83% size:70% based on defining people as having autism, 01:47.874 --> 01:50.210 align:left position:27.5% line:83% size:62.5% we find a bunch of different stuff, 01:50.310 --> 01:53.379 align:left position:22.5% line:83% size:67.5% and that's essentially a problem in our field 01:53.480 --> 01:56.249 align:left position:20% line:89% size:70% because we find too much.